The usual starting dose of Bystolic for most people with high blood pressure is 5 mg once daily. If your blood pressure levels do not improve, your healthcare provider may gradually increase your dose up to a maximum of 40 mg daily. In a placebo-controlled trial of 2128 patients (1067 BYSTOLIC, 1061 placebo) over 70 years of age with chronic heart failure receiving a maximum dose of 10 mg per day for a median of 20 months, no worsening of heart failure was reported with nebivolol compared to placebo. However, if heart failure worsens consider discontinuation of BYSTOLIC. How to use Bystolic. See also Warning section. Read the Patient Information Leaflet if available from your pharmacist before you start taking nebivolol and each time you get a refill. Missed Dose of Bystolic If you miss a dose of Bystolic, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and take your next dose at the regular time. Bystolic is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Follow your diet, medication, and exercise routines very closely. Hypertension. The dose of BYSTOLIC must be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents. The dose of BYSTOLIC must be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents. For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg. A more frequent dosing regimen is unlikely to be beneficial. DOSAGE AND ADMINISTRATION Hypertension. The dose of BYSTOLIC must be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents.